Immunologic Evaluation of Drug Allergy

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Immunologic Evaluation of Drug Allergy

Hypersensitivity drug reactions (HDR) consist of an individual abnormal response with the involvement of the immunological system. In addition to specific immunological mechanisms where specific antibodies or sensitised T cells participate, release of inflammatory mediators by non-specific immunological recognition may also occur. Within this category are one of the most common groups of drugs,...

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New allergy drug excipient allergy

Background Because of its rarity, drug excipients allergy is often unsuspected by the doctors. Some times the active drug is blamed and discontinued unnecessarily when the real culprit is drug excipients. This was suspected when patients reported exacerbation of urticaria with anti histaminic which are actually used for treating urticaria. After suspecting drug excipient as the cause of allergy.

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Drug allergy

Allergic drug reactions occur when a drug, usually a low molecular weight molecule, has the ability to stimulate an immune response. This can be done in one of two ways. The first is by binding covalently to a self-protein, to produce a haptenated molecule that can be processed and presented to the adaptive immune system to induce an immune response. Sometimes the drug itself cannot do this but...

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Drug allergy.

Drug allergy is one type of adverse reaction to drugs and encompasses a spectrum of hypersensitivity reactions with heterogeneous mechanisms and clinical presentations. A thorough history is essential to the management of drug allergy. Laboratory testing has a very limited role in the management of drug allergy. Graded dose challenges and procedures to induce drug tolerance might be required in...

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Drug Allergy

Introduction Adverse reactions to pharmaceutical and diagnostic products constitute a major hazard in the practice of medicine and are responsible for substantial morbidity and cost. Adverse drug reactions can be divided into predictable and unpredictable reactions. Predictable reactions including drug toxicity, drug interactions, and adverse effects are dose dependent, can be related to known ...

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ژورنال

عنوان ژورنال: Allergy, Asthma & Immunology Research

سال: 2012

ISSN: 2092-7355,2092-7363

DOI: 10.4168/aair.2012.4.5.251